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Wednesday, July 8, 2020 | History

2 edition of pharmacologic alteration of renin release found in the catalog.

pharmacologic alteration of renin release

T. Kent Keeton

pharmacologic alteration of renin release

by T. Kent Keeton

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  • 2 Currently reading

Published by Williamsand Wilkins in Baltimore .
Written in English


Edition Notes

Statementby T. Kent Keeton and William B. Campbell.
SeriesPharmacological Reviews -- 32 number 2
ContributionsCampbell, William B.
The Physical Object
Pagination227p. ;
Number of Pages227
ID Numbers
Open LibraryOL13792044M

Abstract. The interaction of hormones, growth factors, or cytokines to their specific cell surface receptors can lead to the stimulation of a cascade of biochemical events including the activation of several phospholipases which in turn can result in the release of several lipid second messengers (1) as outlined. Thus, the action of angiotensin II (AII) or other vascular smooth muscle cell Cited by: 5. Keeton TK, Campbell WB. The pharmacologic alteration of renin release. Pharmacol Rev. Jun; 32 (2)– Munday KA, Noble AR, Richards HK. Active and inactive renin release from rabbit kidney cortex slices: effect of sodium concentration and of furosemide. J Physiol. Jul; – [PMC free article]Cited by: 3.

The pharmacologic alteration of renin release. Pharmacol Rev 81–, PubMed | ISI Google Scholar; 26 Kim HS, Maeda N, Oh GT, Fernandez LG, Gomez RA, Smithies O. Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem –, Cited by: Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase. Hypertension –, Crossref PubMed ISI Google Scholar; 61 Ortiz-Capisano MC, Ortiz PA, Harding P, Garvin JL, Beierwaltes WH. Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension –,

Interaction of Signals Influencing Renin Release Interaction of Signals Influencing Renin Release Gibbons, G H; Dzau, V J; Farhi, E R; Barger, A C The various physiological mechanisms that individually modulate the release of renin from the kidney have been reviewed by a number of investigators (18, 27, 68). It is apparent that the juxtaglomerular cells that release renin.   Long-term preservation of renin-secreting ability by human adult juxtaglomerular tumor cells in explant culture. (PMID PMCID:PMC) Long‐term Preservation of Renin‐secreting Ability by Human Adult Juxtaglomerular Tumor Cells in Explant Culture The pharmacologic alteration of renin release. Pharmacol. Rev., 32, 81 Author: Ubaldo Armato, Domenico D'Agostino, Flora Romano, Angelo Salvetti, Franco Mantero.


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Pharmacologic alteration of renin release by T. Kent Keeton Download PDF EPUB FB2

Pharmacol Rev. Jun;32(2) The pharmacologic alteration of renin release. Keeton TK, Campbell WB. PMID: [PubMed - indexed for MEDLINE]Cited by: The pharmacologic alteration of renin release.

T K Keeton and W B Campbell. Pharmacological Reviews June32 (2) ; Article; Info & Metrics; eLetters; PDF; This is a PDF-only article. The first page of the PDF of this article appears above. PharmRev articles become freely available 12 months after publication, and remain freely Cited by: Appropriate physiologic responses of serum renin activity (SRA) in the unanesthetized rat (1) suggest this highly useful laboratory animal for pharmacologic studies of renin release.

Adrenergic mediation of renin release has been suggested by results of previous investigations in man (2—4), anesthetized animals (5—11) and in vitro studies (12). Anesthesia induces renin release which can explain previously reported unique qualities of the rat renin-angiotensin-aldosterone Cited by: 8.

A pharmacological alteration of renin activity might be beneficial in HF management and results in simultaneous changes of Ang II/Ang (1–7), (P)RR, and IGFII/M6P networks; the interplay of these effects remains to be investigated.

We will focus on DRIs that were primarily designed to block enzymatic activity of by: 2. Keeton TK, Campbell WB. The pharmacologic alteration of renin release. Pharmacol Rev. Jun; 32 (2)– Kurtz A, Pfeilschifter J, Hutter A, Bührle C, Nobiling R, Taugner R, Hackenthal E, Bauer C.

Role of protein kinase C in inhibition of renin release caused by vasoconstrictors. Am J Physiol. Apr; (4 Pt 1):C–CCited by: The Effect of Calcium on Renin, Aldosterone and Prostaglandin Release. Abstract. Evidence suggests that calcium (Ca 2+) has an important regulatory role in the control of systemic and renal vascular tone.

Acute and chronic hypercalcemia can increase blood pressure (Bp) and reduce renal blood flow (1–3).Cited by: 1. Central Journal of Pharmacology & Clinical Toxicology Cite this article: Speth RC, Giese MJ () Update on the Renin-Angiotensin System.

J Pharmacol Clin Toxicol 1(1): *Corresponding author Robert C. Speth, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern. Renin release from individual afferent-glomerular units was measured in 30 minute intervals while afferent arteriolar pressure was either decreased from 55 to 40 to 25 mm Hg or increased from 25 to 40 to 55 mm Hg.

There was a clear, inverse relation of renin release Cited by: Renin release from JG cells determines RAS activity and the process is known to be regulated by intracellular cAMP (Peters et al., ;Gambaryan et al. Cyclosporine A enhances renin secretion and production in isolated juxtaglomerular cells.

Stimulation of the renin-angiotensin system is a major side effect of the fungoid immunosuppressant cyclosporine A (CyA).Cited by: Furthermore, angiotensin II induces proatherosclerotic cytokine and chemokine secretion and increases endothelial dysfunction. Accordingly, the pharmacological inhibition of the renin-angiotensin system improves prognosis of patients with cardiovascular disease even in settings of normal baseline blood pressure.

Plasma renin activity was significantly augmented in the valsartan-treated group, and it was significantly attenuated in the valsartan+cilnidipine-treated group. A significant increase in the ratio of plasma angiotensin- () to angiotensin II was observed only in the valsartan+cilnidipine-treated group.

Renin activity in the adrenal homogenate, medium, and plasma from TGR rats was completely inhibited by the renin inhibitor (CP ; 1 microM), but only slightly inhibited ( +/.

Active and inactive renin release by rabbit kidney cortex slices was investigated. Inactive renin was estimated as the increase in renin activity after acidification (pH 2. 8) of slice supernatant solutions. Active renin release was increased when incubation medium [Na+] was reduced.

This relationship was linear (r2 = by: Ontogeny of isoproterenol-stimulated renin secretion from sheep renal cortical slices. Am J Physiol. Jun; (6 Pt 2):R–R Keeton TK, Campbell WB. The pharmacologic alteration of renin release. Pharmacol Rev. Jun; 32 (2)– Davis JO, Freeman RH.

Mechanisms regulating renin by: The effect of aminophylline on renin release from human chorion was investigated by perfusing the tissue with various concentrations of the drug. Buffer containing aminophylline (2×10 −6 mol/l) doubled the rate of active and total renin secretion, but a more concentrated solution (10 −5 mol/l) released proportionately less active and total Cited by: 2.

Pharmacological Modulation of the Renin-Angiotensin System by Mathematical Modeling Pérez-Rosas, N. and Rodríguez-González, J.* Centro de Investigación y. The renin-angiotensinaldosterone hormonal system and regulation of sodium, potassium, and blood pressure homeostasis.

In J. Orloff & R. Berliner (Eds.), Handbook of physiology: Renal physiology (pp. –).Author: Steven A. Atlas, Jean E.

Sealey, John H. Laragh. This study (1) provides the first comprehensive set of basal values for hemodynamic variables, plasma norepinephrine (NE) and epinephrine concentrations and plasma renin activity in the conscious cat and (2) demonstrates that changes in plasma NE concentration in the conscious cat accurately reflect the alterations in sympathetic discharge caused by hydralazine, yohimbine, Cited by: Abstract.

The renin-angiotensin system plays a central role in salt and water balance and in the regulation of arterial blood pressure. The level of activity of this system is determined primarily by the rate at which the granulated juxtaglomerular cells (JG cells) secrete renin into the : P.

Churchill. Renin release from single rat afferent arterioles is discontinous with a renin content per discharge, which corresponds to the calculated renin content of one secretory granule.

The spontaneous discharge rate was rather slow, with a release episode occurring every 5 .K. Brocklehurst, Specific covalent modification of thiols: Applications in the study of enzymes and other biomolecules Int J Biochem () A.J.

Vander, Control of renin release Physiol Rev () T.K. Keeton, W.B. Campbell, The pharmacologic alteration of renin release Pharmacol Rev () Cited by: 2. ANG-II ROLES – CONTD. Pharmacological implications: Drugs Increasing Renin release: ACE inhibitors and AT1 receptor antagonists enhance Renin release Vasodilators and diuretics stimulate Renin release Loop diuretics increase renin release Decrease in Renin release: Beta blockers and central sympatholytics NSAIDs and selective .